Prenatal Stress
How chronic maternal stress during pregnancy affects fetal and neonatal neurodevelopment, and early detection strategies.
Neuroinflammation
Fetal brain inflammation mechanisms, the cholinergic anti-inflammatory pathway, and microglial responses.
Brain Ischemia
Early and reliable detection of fetal brain injury using heart rate variability as a non-invasive biomarker.
ECG Biosensors
Non-invasive fetal ECG monitoring to identify fetuses developing acidemia using HRV analysis.
EEG Monitoring
Fetal EEG during labor to predict severe acidemia and prevent brain injury through early intervention.
In Silico Models
Computational simulation of labor physiology and fetal cardiovascular responses.
Our Mission
The health of mothers, fathers, and infants sets the stage for a lifetime of well-being. Neglecting this critical window has profound, multi-generational impacts on families and economies. We believe that investing in early-life health brings the highest ROI in healthcare, which is why the Frasch Lab is dedicated to pioneering solutions through prevention and early detection.
About the Lab
The Frasch Lab studies the brain’s responses to asphyxia, inflammation/infection, and stress during the perinatal period. We apply machine learning and AI frameworks to convert medical data into physiological phenotypes with individualized predictive potential.
Our work emphasizes non-invasive monitoring technologies (ECG, EEG) to identify at-risk babies, and preclinical research examining how prenatal harmful events shape brain development—particularly regarding glial biology, microglia, and astrocytes relevant to neuroinflammatory and neurodegenerative diseases.